Gallic acid disruption of Aβ1–42 aggregation rescues cognitive decline of APP/PS1 double transgenic mouse

Gallic acid disruption of Aβ1–42 aggregation rescues cognitive decline of APP/PS1 double transgenic mouse

Alzheimer's disease (AD) treatment represents one of the largest unmet medical needs. Developing small molecules targeting Aβ aggregation is an effective approach to prevent and treat AD. Here, we show that gallic acid (GA), a naturally occurring polyphenolic small molecule rich in grape seeds...

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Bibliographic Details
Main Authors: Mei Yu, Xuwei Chen, Jihong Liu, Quan Ma, Zhan Zhuo, Hao Chen, Lin Zhou, Sen Yang, Lifeng Zheng, Chengqing Ning, Jing Xu, Tianming Gao, Sheng-Tao Hou
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Gallic acid
Amyloid-β-aggregation
Morris water maze
Novel object recognition test
Y-maze
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118302067

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http://www.sciencedirect.com/science/article/pii/S0969996118302067

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