Early Life Stress Alters Expression of Glucocorticoid Stress Response Genes and Trophic Factor Transcripts in the Rodent Basal Ganglia

Early Life Stress Alters Expression of Glucocorticoid Stress Response Genes and Trophic Factor Transcripts in the Rodent Basal Ganglia

Early life stress shapes the developing brain and increases risk for psychotic disorders. Yet, it is not fully understood how early life stress impacts brain regions in dopaminergic pathways whose dysfunction can contribute to psychosis. Therefore, we investigated gene expression following early lif...

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Bibliographic Details
Main Authors: Cynthia Haidee Tran, Cynthia Shannon Weickert, Thomas Wesley Weickert, Duncan Sinclair
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
early life stress
brain-derived neurotrophic factor
BDNF
glucocorticoid receptor
FKBP5
dopamine
Online Access:https://www.mdpi.com/1422-0067/23/10/5333

Internet

https://www.mdpi.com/1422-0067/23/10/5333

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