The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells

The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells

Abstract Disease recurrence following chemotherapy is a major clinical challenge in ovarian cancer (OC), but little is known regarding how the tumour epigenome regulates transcriptional programs underpinning chemoresistance. We determine the single cell chromatin accessibility landscape of omental O...

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Bibliographic Details
Main Authors: W. Croft, R. Pounds, D. Jeevan, K. Singh, J. Balega, S. Sundar, A. Williams, R. Ganesan, S. Kehoe, S. Ott, J. Zuo, J. Yap, P. Moss
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06909-9

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https://doi.org/10.1038/s42003-024-06909-9

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