Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI

Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI

Optimal treatment selection for localized renal tumors is challenging due to their variable biological behavior and limited ability to pre-operatively assess their aggressiveness. We investigated hyperpolarized (HP) 13C pyruvate MRI to noninvasively assess tumor lactate production and compartmentali...

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Bibliographic Details
Main Authors: Renuka Sriram, Jeremy Gordon, Celine Baligand, Fayyaz Ahamed, Justin Delos Santos, Hecong Qin, Robert A. Bok, Daniel B. Vigneron, John Kurhanewicz, Peder E. Z. Larson, Zhen J. Wang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
hyperpolarized 13C magnetic resonance imaging (HP 13C MRI)
dynamic nuclear polarization (DNP)
aerobic glycolysis
lactate dehydrogenase (LDH)
lactate efflux
renal cell carcinoma (RCC)
Online Access:http://www.mdpi.com/2072-6694/10/9/313

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http://www.mdpi.com/2072-6694/10/9/313

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