Novel Disease-Associated Missense Single-Nucleotide Polymorphisms Variants Predication by Algorithms Tools and Molecular Dynamics Simulation of Human TCIRG1 Gene Causing Congenital Neutropenia and Osteopetrosis

Novel Disease-Associated Missense Single-Nucleotide Polymorphisms Variants Predication by Algorithms Tools and Molecular Dynamics Simulation of Human TCIRG1 Gene Causing Congenital Neutropenia and Osteopetrosis

T Cell Immune Regulator 1, ATPase H + Transporting V0 Subunit A3 (TCIRG1 gene provides instructions for making one part, the a3 subunit, of a large protein complex known as a vacuolar H + -ATPase (V-ATPase). V-ATPases are a group of similar complexes that act as pumps to move positively charged hydr...

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Bibliographic Details
Main Authors: Khyber Shinwari, Hafiz Muzzammel Rehman, Guojun Liu, Mikhail A. Bolkov, Irina A. Tuzankina, Valery. A. Chereshnev
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
TCIRG1 gene mutation
congenital neutropenia
osteopetrosis
non-synonymous single nucleotide polymorphisms
molecular dynamics simulation (MD)
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.879875/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.879875/full

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