Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation

Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation

Abstract Background The prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although metalloimmunotherapy has shown potential in combating tumor proliferation, recurrence and metastasis, current apoptosis-based metalloimmunotherapy...

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Bibliographic Details
Main Authors: Qianying Du, Ying Luo, Lian Xu, Chier Du, Wenli Zhang, Jie Xu, Yun Liu, Bo Liu, Sijin Chen, Yi Wang, Zhigang Wang, Haitao Ran, Junrui Wang, Dajing Guo
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Nanobiotechnology
Subjects:
Bimetallic nanovaccine
Pyroptosis
cGAS-STING
Hepatocellular carcinoma
Magnetic resonance imaging
Online Access:https://doi.org/10.1186/s12951-024-02354-2

Internet

https://doi.org/10.1186/s12951-024-02354-2

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