Identification of stage-specific gene expression signatures in response to retinoic acid during the neural differentiation of mouse embryonic stem cells

Identification of stage-specific gene expression signatures in response to retinoic acid during the neural differentiation of mouse embryonic stem cells

AbstractWe have previously established a protocol for the neural differentiation of mouse embryonic stem cells (mESCs) as an efficient tool to evaluate the neurodevelopmental toxicity of environmental chemicals. Here, we described a multivariate bioinformatic approach to identify the stage-specific...

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Bibliographic Details
Main Authors: Hiromi eAkanuma, Xian-Yang eQin, Reiko eNagano, Tin-Tin eWin-Shwe, Satoshi eImanishi, Hiroko eZaha, Tomokazu eFukuda, Jun eYoshinaga, Seiichiroh eOhsako, Hideko eSone
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Genetics
Subjects:
Principal Component Analysis
Bayesian network
neural differentiation
Retinoic acid
mouse embryonic stem cells
self-organizing map
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00141/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00141/full

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