Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants

Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants

Despite the growing knowledge of T cell responses in COVID-19 patients, there is a lack of detailed characterizations for T cell-antigen interactions and T cell functions. Here, with a predicted peptide library from SARS-CoV-2 S and N proteins, we found that specific CD8+ T cell responses were ident...

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Bibliographic Details
Main Authors: Chao Hu, Meiying Shen, Xiaojian Han, Qian Chen, Luo Li, Siyin Chen, Jing Zhang, Fengxia Gao, Wang Wang, Yingming Wang, Tingting Li, Shenglong Li, Jingjing Huang, Jianwei Wang, Ju Zhu, Dan Chen, Qingchen Wu, Kun Tao, Da Pang, Aishun Jin
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-01-01
Series:Genes and Diseases
Subjects:
CD8+T cell
HLA class I
Lung organoid
SARS-CoV-2
T cell epitope
TCR
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304221000842

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http://www.sciencedirect.com/science/article/pii/S2352304221000842

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