CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4‐Fatty Acid β‐Oxidation Pathway

CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4‐Fatty Acid β‐Oxidation Pathway

Abstract Metabolic reprogramming is often observed in carcinogenesis, but little is known about the aberrant metabolic genes involved in the tumorigenicity and maintenance of stemness in cancer cells. Sixty‐seven oncogenic metabolism‐related genes in liver cancer by in vivo CRISPR/Cas9 screening are...

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Bibliographic Details
Main Authors: Hongquan Li, Junjiao Song, Yifei He, Yizhe Liu, Zhen Liu, Weili Sun, Weiguo Hu, Qun‐Ying Lei, Xin Hu, Zhiao Chen, Xianghuo He
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Advanced Science
Subjects:
ACSL4
cancer cell stemness
fatty acid β‐oxidation
hexokinase 2
Online Access:https://doi.org/10.1002/advs.202105126

Internet

https://doi.org/10.1002/advs.202105126

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