Identification of Splicing Quantitative Trait Loci (sQTL) in Drosophila melanogaster with Developmental Lead (Pb2+) Exposure

Identification of Splicing Quantitative Trait Loci (sQTL) in Drosophila melanogaster with Developmental Lead (Pb2+) Exposure

Lead (Pb) poisoning has been a major public health issue globally and the recent Flint water crisis has drawn nation-wide attention to its effects. To better understand how lead plays a role as a neurotoxin, we utilized the Drosophila melanogaster model to study the genetic effects of lead exposure...

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Bibliographic Details
Main Authors: Wen Qu, Katherine Gurdziel, Roger Pique-Regi, Douglas M. Ruden
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Genetics
Subjects:
developmental lead exposure
Drosophila melanogaster
splicing quantitative trait loci (sQTL or splice QTL)
Drosophila synthetic population resource (DSPR)
RNA-seq
toxicogenomics
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2017.00145/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2017.00145/full

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