MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM-like cells.

MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM-like cells.

CD4+ tissue resident memory T cells (TRMs) are implicated in the formation of persistent HIV reservoirs that are established during the very early stages of infection. The tissue-specific factors that direct T cells to establish tissue residency are not well defined, nor are the factors that establi...

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Bibliographic Details
Main Authors: Sinmanus Vimonpatranon, Livia R Goes, Amanda Chan, Isabella Licavoli, Jordan McMurry, Samuel R Wertz, Anush Arakelyan, Dawei Huang, Andrew Jiang, Cindy Huang, Joyce Zhou, Jason Yolitz, Alexandre Girard, Donald Van Ryk, Danlan Wei, Il Young Hwang, Craig Martens, Kishore Kanakabandi, Kimmo Virtaneva, Stacy Ricklefs, Benjamin P Darwitz, Marcelo A Soares, Kovit Pattanapanyasat, Anthony S Fauci, James Arthos, Claudia Cicala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011209

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https://doi.org/10.1371/journal.ppat.1011209

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