The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells

The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells

Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), which can progress to end stage renal disease (ESRD), are a worldwide health burden. Organ transplantation or kidney dialysis are the only effective available therapeutic tools. Therefore, in vitro models of kidne...

Full description

Bibliographic Details
Main Authors:	Lisa Nguyen, Wasco Wruck, Lars Erichsen, Nina Graffmann, James Adjaye
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Cells
Subjects:	urine cells iPSCs organoids puromycin aminonucleoside AKI inflammation
Online Access:	https://www.mdpi.com/2073-4409/11/4/635

Similar Items

Puromycin aminonucleoside‐induced podocyte injury is ameliorated by the Smad3 inhibitor SIS3
by: Lina Jiang, et al.
Published: (2020-08-01)

Puromycin aminonucleoside triggers apoptosis in podocytes by inducing endoplasmic reticulum stress
by: Seo-Yoon Min, et al.
Published: (2018-09-01)

Puromycin aminonucleoside modulates p130Cas of podocytes
by: Tae-Sun Ha, et al.
Published: (2012-10-01)

The Role of <i>miR-217-5p</i> in the Puromycin Aminonucleoside-Induced Morphological Change of Podocytes
by: Osamu Ishibashi, et al.
Published: (2022-06-01)

Experimentally induced puromycine aminonucleoside nephrosis (PAN) in rats: evaluation of angiogenic protein platelet-derived endothelial cell growth factor (PD-ECGF) expression in glomeruli
by: Seckin Ismail, et al.
Published: (2012-02-01)

Correction: Nguyen et al. The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells. <i>Cells</i> 2022, <i>11</i>, 635
by: Lisa Nguyen, et al.
Published: (2022-06-01)

Renal protective effects of helix B surface polypeptide in rats with puromycin aminonucleoside nephropathy
by: Ting Chen, et al.
Published: (2024-12-01)

Salvia przewalskii extract of total phenolic acids inhibit TLR4 signaling activation in podocyte injury induced by puromycin aminonucleoside in vitro
by: Hongqi Ren, et al.
Published: (2018-10-01)

Pharmacological Melanocortin 5 Receptor Activation Attenuates Glomerular Injury and Proteinuria in Rats With Puromycin Aminonucleoside Nephrosis
by: Bohan Chen, et al.
Published: (2022-06-01)

Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models
by: Abida Islam Pranty, et al.
Published: (2022-08-01)

Impaired p53-Mediated DNA Damage Response Contributes to Microcephaly in Nijmegen Breakage Syndrome Patient-Derived Cerebral Organoids
by: Soraia Martins, et al.
Published: (2022-02-01)

Monocytes prevent apoptosis of iPSCs and promote differentiation of kidney organoids
by: Ekaterina Pecksen, et al.
Published: (2024-05-01)

A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids
by: Yu Takahashi, et al.
Published: (2018-01-01)

Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies
by: Douglas Bottega Pazzin, et al.
Published: (2024-04-01)

GLOMERULAR CAPILLARY GROWTH AND CELLULAR HYPERPLASIA IN A MODEL OF FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS
by: John F Bertram, et al.
Published: (2011-05-01)

Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems
by: Rita Silva-Pedrosa, et al.
Published: (2023-03-01)

Patient-Derived Induced Pluripotent Stem Cells and Organoids for Modeling Alpha Synuclein Propagation in Parkinson's Disease
by: Yong Hui Koh, et al.
Published: (2018-11-01)

Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids
by: Lonneke H. Gaykema, et al.
Published: (2023-01-01)

Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity
by: Wasco Wruck, et al.
Published: (2021-09-01)

Decellularization of Mouse Kidneys to Generate an Extracellular Matrix Gel for Human Induced Pluripotent Stem Cell Derived Renal Organoids
by: Sparshita Nag, et al.
Published: (2023-03-01)

Cerebral Organoids—Challenges to Establish a Brain Prototype
by: Artem V. Eremeev, et al.
Published: (2021-07-01)

Identity and Maturity of iPSC-Derived Oligodendrocytes in 2D and Organoid Systems
by: Ella Zeldich, et al.
Published: (2024-04-01)

Human fibroblasts facilitate the generation of iPSCs-derived mammary-like organoids
by: Xueqin Dai, et al.
Published: (2022-07-01)

Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish
by: Soonil Koun, et al.
Published: (2023-12-01)

Modeling oxidative injury response in human kidney organoids
by: Aneta Przepiorski, et al.
Published: (2022-02-01)

The Potential Clinical Use of Stem/Progenitor Cells and Organoids in Liver Diseases
by: Christina Nikokiraki, et al.
Published: (2022-04-01)

Strategies for Improving Vascularization in Kidney Organoids: A Review of Current Trends
by: Ran Konoe, et al.
Published: (2023-03-01)

Hemozoin induces malaria via activation of DNA damage, p38 MAPK and neurodegenerative pathways in a human iPSC-derived neuronal model of cerebral malaria
by: Abida Islam Pranty, et al.
Published: (2024-10-01)

An induced pluripotent stem cell-based approach for hair follicle development and regeneration
by: Poornima Sivamani, et al.
Published: (2024-06-01)

Design of neural organoids engineered by mechanical forces
by: Dang Ngoc Anh Suong, et al.
Published: (2024-06-01)

Modeling neuropsychiatric disorders using human induced pluripotent stem cells
by: Meiyan Wang, et al.
Published: (2019-05-01)

Exposure to the antiretroviral drug dolutegravir impairs structure and neurogenesis in a forebrain organoid model of human embryonic cortical development
by: Emma LaNoce, et al.
Published: (2024-11-01)

Puromycin reactivity does not accurately localize translation at the subcellular level
by: Syed Usman Enam, et al.
Published: (2020-08-01)

Free Bilirubin Induces Neuro-Inflammation in an Induced Pluripotent Stem Cell-Derived Cortical Organoid Model of Crigler-Najjar Syndrome
by: Abida Islam Pranty, et al.
Published: (2023-09-01)

Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids
by: Guoqiang Sun, et al.
Published: (2020-04-01)

Cerebral Malaria Model Applying Human Brain Organoids
by: Rita Silva-Pedrosa, et al.
Published: (2023-03-01)

Modeling brain macrophage biology and neurodegenerative diseases using human iPSC-derived neuroimmune organoids
by: Jonas Cerneckis, et al.
Published: (2023-06-01)

Repository corticotropin injection versus corticosteroids for protection against renal damage in a focal segmental glomerulosclerosis rodent model
by: Kyle Hayes, et al.
Published: (2020-06-01)

Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies
by: Giulia Magni, et al.
Published: (2024-03-01)

Effects of macrophages on the proliferation and cardiac differentiation of human induced pluripotent stem cells
by: Canling Long, et al.
Published: (2022-07-01)