Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish

Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish

Abstract Esketamine (EK) has been widely used in the treatment of depression, but the effects of EK prenatal treatment on embryonic heart development have been rarely reported. This study assesses the effects of varying concentrations of EK on embryonic development and cardiogenesis to determine the...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Shuang Li, Xiang Li, Rui Zhao, Tingyu Jiang, Qiuyun Ou, Huansen Huang, Jiancheng Tang
Format:	Artikel
Sprache:	English
Veröffentlicht:	Nature Portfolio 2025-02-01
Schriftenreihe:	Scientific Reports
Online Zugang:	https://doi.org/10.1038/s41598-025-91315-2

Ähnliche Einträge

Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos.
von: Chi-Tang Tu, et al.
Veröffentlicht: (2009-01-01)

Activation of the Nkx2.5–Calr–p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish
von: Yanyi Sun, et al.
Veröffentlicht: (2017-10-01)

Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.
von: Daniel R Carter, et al.
Veröffentlicht: (2014-01-01)

GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.
von: Brewer, A, et al.
Veröffentlicht: (2005)

The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
von: Jenny Schlesinger, et al.
Veröffentlicht: (2011-02-01)

nkx2.7 transcription factor is involved in zebrafish cardiac development
von: Simoes, A, et al.
Veröffentlicht: (2007)

Esketamine Exposure Impairs Cardiac Development and Function in Zebrafish Larvae
von: Shuo Huang, et al.
Veröffentlicht: (2024-06-01)

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases
von: Ce Cao, et al.
Veröffentlicht: (2023-12-01)

Cardiac gene activation analysis in mammalian non-myoblasic cells by Nkx2-5, Tbx5, Gata4 and Myocd.
von: Lei Zhou, et al.
Veröffentlicht: (2012-01-01)

Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene
von: Christiane Fuchs, et al.
Veröffentlicht: (2016-02-01)

NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.
von: Ali M Riazi, et al.
Veröffentlicht: (2009-05-01)

Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
von: Eun Young Kim, et al.
Veröffentlicht: (2011-01-01)

Affinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4
von: Mikael Jumppanen, et al.
Veröffentlicht: (2024-04-01)

GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation.
von: Peterkin, T, et al.
Veröffentlicht: (2003)

Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing
von: Peter G. Farlie, et al.
Veröffentlicht: (2017-07-01)

The broad role of Nkx3.2 in the development of the zebrafish axial skeleton.
von: Laura Waldmann, et al.
Veröffentlicht: (2021-01-01)

nkx2.1 and nkx2.4 genes function partially redundant during development of the zebrafish hypothalamus, preoptic region, and pallidum
von: Wolfgang eDriever, et al.
Veröffentlicht: (2014-12-01)

Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts
von: Leyre López-Muneta, et al.
Veröffentlicht: (2022-01-01)

Cardiac transcription factor Nkx2.5 is downregulated under excessive O-GlcNAcylation condition.
von: Hoe Suk Kim, et al.
Veröffentlicht: (2012-01-01)

Non‐invasive lung cancer diagnosis by detection of GATA6 and NKX2‐1 isoforms in exhaled breath condensate
von: Aditi Mehta, et al.
Veröffentlicht: (2016-11-01)

BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish.
von: Linwei Li, et al.
Veröffentlicht: (2019-02-01)

Analysis of genetic polymorphisms of TBX5, NKX2-5 and GATA4 cardiac transcription factor genes in Malaysian non syndromic congenital heart disease subjects
von: Khadhim, Nora F.
Veröffentlicht: (2012)

Prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillation
von: Wen-Hui Xie, et al.
Veröffentlicht: (2013-06-01)

Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish
von: Kendall E Martin, et al.
Veröffentlicht: (2023-05-01)

The impact of esketamine on cardiac function in patients undergoing anesthesia
von: Edward Sun, et al.
Veröffentlicht: (2025-03-01)

Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish
von: Oscar A. Peña, et al.
Veröffentlicht: (2021-09-01)

Association of NFKB1, NKX2-5, GATA4 and RANKL gene polymorphisms with sporadic congenital heart disease in Greek patients
von: Aidinidou L, et al.
Veröffentlicht: (2021-07-01)

Activation of Nkx2.5 transcriptional program is required for adult myocardial repair
von: Carmen de Sena-Tomás, et al.
Veröffentlicht: (2022-05-01)

Nkx2.5 Based Ventricular Programming of Murine ESC-Derived Cardiomyocytes
von: Frauke Thiele, et al.
Veröffentlicht: (2019-08-01)

Myeloid zinc finger 1 (Mzf1) differentially modulates murine cardiogenesis by interacting with an Nkx2.5 cardiac enhancer.
von: Stefanie A Doppler, et al.
Veröffentlicht: (2014-01-01)

Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1
von: Songwei Wang, et al.
Veröffentlicht: (2024-09-01)

The regulation of troponins I, C and ANP by GATA4 and Nkx2-5 in heart of hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus.
von: Bryan E Luu, et al.
Veröffentlicht: (2015-01-01)

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.
von: Risebro, C, et al.
Veröffentlicht: (2012)

Generation of a human embryonic stem cell line (SKLRMe004-A) carrying NKX2.5-EGFP and TBX5-Tdtomato dual fluorescent reporters
von: Zhazheng He, et al.
Veröffentlicht: (2023-03-01)

Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta
von: Lyad Zamir, et al.
Veröffentlicht: (2017-03-01)

NKX2.5 is expressed in papillary thyroid carcinomas and regulates differentiation in thyroid cells
von: Ricardo Cortez Cardoso Penha, et al.
Veröffentlicht: (2018-05-01)

Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility
von: Cheng Kai-Chun, et al.
Veröffentlicht: (2011-06-01)

Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5
von: Costa, M, et al.
Veröffentlicht: (2011)

Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation
von: Wenyu Hu, et al.
Veröffentlicht: (2021-02-01)

Embryonic malformations in an offspring of the shortnose guitarfish
von: Natascha Wosnick, et al.
Veröffentlicht: (2019-10-01)