Indomethacin Induces Spermidine/Spermine-N<sup>1</sup>-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells

Indomethacin Induces Spermidine/Spermine-N<sup>1</sup>-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells

Indomethacin is a non-selective NSAID used against pain and inflammation. Although cyclooxygenase (COX) inhibition is considered indomethacin’s primary action mechanism, COX-independent ways are associated with beneficial effects in cancer. In colon cancer cells, the activation of the peroxisome pro...

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Bibliographic Details
Main Authors: Neudo Buelvas, Isidora Ugarte-Vio, Laura Asencio-Leal, Matías Muñoz-Uribe, Antonia Martin-Martin, Alejandro Rojas-Fernández, José A. Jara, Julio C. Tapia, María Elena Arias, Rodrigo A. López-Muñoz
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomolecules
Subjects:
polyamines
cancer
indomethacin
non-steroidal anti-inflammatory drugs
Online Access:https://www.mdpi.com/2218-273X/13/9/1383

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https://www.mdpi.com/2218-273X/13/9/1383

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