Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions.

Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions.

Misregulation and mutations of the transcription factor Nrf2 are involved in the development of a variety of human diseases. In this study, we employed the technology of stapled peptides to address a protein-DNA-complex and designed a set of Nrf2-based derivatives. Varying the length and position of...

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Main Authors: Bianca Wiedemann, Dominic Kamps, Laura Depta, Jörn Weisner, Jana Cvetreznik, Stefano Tomassi, Sascha Gentz, Jan-Erik Hoffmann, Matthias P Müller, Oliver Koch, Leif Dehmelt, Daniel Rauh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0267651

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https://doi.org/10.1371/journal.pone.0267651

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