Autocrine BMP4 Signaling Enhances Tumor Aggressiveness via Promoting Wnt/β-Catenin Signaling in IDH1-mutant Gliomas

Autocrine BMP4 Signaling Enhances Tumor Aggressiveness via Promoting Wnt/β-Catenin Signaling in IDH1-mutant Gliomas

The isocitrate dehydrogenase (IDH1/2) mutations are frequent genetic abnormalities in the majority of WHO grade II/III glioma and secondary GBM. IDH1-mutated (IDH1Mut) glioma exhibits distinctive patterns in cancer biology and metabolism. In the present study, we showed that bone morphogenetic prote...

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Bibliographic Details
Main Authors: Yiqiang Zhou, Yang Liu, Junwen Zhang, Di Yu, Aiguo Li, Hua Song, Wei Zhang, Dionne Davis, Mark R. Gilbert, Fusheng Liu, Chunzhang Yang
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S193652331930436X

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http://www.sciencedirect.com/science/article/pii/S193652331930436X

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