Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

Abstract Exosomes are well-known key mediators of intercellular communication and contribute to various physiological and pathological processes. Their biogenesis involves four key steps, including cargo sorting, MVB formation and maturation, transport of MVBs, and MVB fusion with the plasma membran...

Full description

Bibliographic Details
Main Authors: Qing-Fang Han, Wen-Jia Li, Kai-Shun Hu, Jie Gao, Wen-Long Zhai, Jing-Hua Yang, Shui-Jun Zhang
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12943-022-01671-0