Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation

The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasome’s regulatory particle, consisting of lid and base subcomplexes, undergoes major confo...

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Autori principali: Eric R Greene, Ellen A Goodall, Andres H de la Peña, Mary E Matyskiela, Gabriel C Lander, Andreas Martin
Natura: Articolo
Lingua:English
Pubblicazione: eLife Sciences Publications Ltd 2019-11-01
Serie:eLife
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Accesso online:https://elifesciences.org/articles/49806