Development of a CD8+ T cell-based molecular classification for predicting prognosis and heterogeneity in triple-negative breast cancer by integrated analysis of single-cell and bulk RNA-sequencing

Development of a CD8+ T cell-based molecular classification for predicting prognosis and heterogeneity in triple-negative breast cancer by integrated analysis of single-cell and bulk RNA-sequencing

Background: Triple-negative breast cancer (TNBC), although the most intractable subtype, is characterized by abundant immunogenicity, which enhances responsiveness to immunotherapeutic measures. Methods: First, we identified CD8+ T cell core genes (TRCG) based on single-cell sequence and traditional...

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Bibliographic Details
Main Authors: Yin-wei Dai, Wei-ming Wang, Xiang Zhou
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Heliyon
Subjects:
Triple-negative breast cancer
CD8+ T cell
single cell sequencing
Heterogeneity
Tumor immune microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023070068

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http://www.sciencedirect.com/science/article/pii/S2405844023070068

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