An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents

An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents

We describe the synthesis of C8-alkynyl adenine pyranonucleosides 4, 5 and 8-phenylethynyl-adenine (II), via Sonogashira cross-coupling reaction under microwave irradiation. Compounds 4e and II were less cytostatic than 5-fluorouracil (almost an order of magnitude) against murine leukemia (L1210) an...

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Bibliographic Details
Main Authors: Athina eDimopoulou, Stella eManta, Vanessa eParmenopoulou, Nikolaos eKollatos, Ourania eChristidou, Virginia eTriantakonstanti, Dominique eSchols, Dimitri eKomiotis
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Chemistry
Subjects:
cytotoxic activity
Microwave irradiation
Sonogashira coupling reaction
8-bromoadenine
N6-benzoyladenine pyranonucleosides
Online Access:http://journal.frontiersin.org/Journal/10.3389/fchem.2015.00021/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fchem.2015.00021/full

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