PPARs and Their Neuroprotective Effects in Parkinson’s Disease: A Novel Therapeutic Approach in α-Synucleinopathy?

PPARs and Their Neuroprotective Effects in Parkinson’s Disease: A Novel Therapeutic Approach in α-Synucleinopathy?

Parkinson’s disease (PD) is the most common α-synucleinopathy worldwide. The pathognomonic hallmark of PD is the misfolding and propagation of the α-synuclein (α-syn) protein, observed in post-mortem histopathology. It has been hypothesized that α-synucleinopathy triggers oxidative stress, mitochond...

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Bibliographic Details
Main Authors: Isaac Pérez-Segura, Alberto Santiago-Balmaseda, Luis Daniel Rodríguez-Hernández, Adriana Morales-Martínez, Hilda Angélica Martínez-Becerril, Paola A. Martínez-Gómez, Karen M. Delgado-Minjares, Citlaltepetl Salinas-Lara, Irma A. Martínez-Dávila, Magdalena Guerra-Crespo, Francisca Pérez-Severiano, Luis O. Soto-Rojas
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
α-synucleinopathy
neuroprotection
Parkinson’s disease
Lewy bodies
PPAR
glitazones
Online Access:https://www.mdpi.com/1422-0067/24/4/3264

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https://www.mdpi.com/1422-0067/24/4/3264

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