Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination

Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination

The cuprizone (CPZ)-induced demyelination model, an animal model of Multiple sclerosis (MS), is characterized by demyelination and motor dysfunction due to microglial-mediated neuroinflammation. To determine the contribution of microglia to motor function during CPZ-induced demyelination, the microg...

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Bibliographic Details
Main Authors: Shinji Yamamoto, Kensuke Iwasa, Anzu Yamagishi, Chikara Haruta, Kei Maruyama, Keisuke Yoshikawa
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Microglia
PLX3397
Superior cerebellar peduncle
Cuprizone
Multiple sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000488

Internet

http://www.sciencedirect.com/science/article/pii/S1347861323000488

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