Pseudomonas Exotoxin A Based Toxins Targeting Epidermal Growth Factor Receptor for the Treatment of Prostate Cancer

The epidermal growth factor receptor (EGFR) was found to be a valuable target on prostate cancer (PCa) cells. However, EGFR inhibitors mostly failed in clinical studies with patients suffering from PCa. We therefore tested the targeted toxins EGF-PE40 and EGF-PE24mut consisting of the natural ligand...

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Detalhes bibliográficos
Main Authors: Alexandra Fischer, Isis Wolf, Hendrik Fuchs, Anie Priscilla Masilamani, Philipp Wolf
Formato: Artigo
Idioma:English
Publicado em: MDPI AG 2020-11-01
Colecção:Toxins
Assuntos:
Acesso em linha:https://www.mdpi.com/2072-6651/12/12/753