Pseudomonas Exotoxin A Based Toxins Targeting Epidermal Growth Factor Receptor for the Treatment of Prostate Cancer

Pseudomonas Exotoxin A Based Toxins Targeting Epidermal Growth Factor Receptor for the Treatment of Prostate Cancer

The epidermal growth factor receptor (EGFR) was found to be a valuable target on prostate cancer (PCa) cells. However, EGFR inhibitors mostly failed in clinical studies with patients suffering from PCa. We therefore tested the targeted toxins EGF-PE40 and EGF-PE24mut consisting of the natural ligand...

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Bibliographic Details
Main Authors: Alexandra Fischer, Isis Wolf, Hendrik Fuchs, Anie Priscilla Masilamani, Philipp Wolf
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Toxins
Subjects:
prostate cancer
targeted toxins
epidermal growth factor
epidermal growth factor receptor
<i>Pseudomonas</i> Exotoxin A
Online Access:https://www.mdpi.com/2072-6651/12/12/753

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