Optical projection tomography as a quantitative tool for analysis of cell morphology and density in 3D hydrogels

Abstract Assessing cell morphology and function, as well as biomaterial performance in cell cultures, is one of the key challenges in cell biology and tissue engineering (TE) research. In TE, there is an urgent need for methods to image actual three-dimensional (3D) cell cultures and access the livi...

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Bibliographic Details
Main Authors: Birhanu Belay, Janne T. Koivisto, Jenny Parraga, Olli Koskela, Toni Montonen, Minna Kellomäki, Edite Figueiras, Jari Hyttinen
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85996-8