PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1α

PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1α

Hypoxia induces a series of cellular adaptive responses that enable promotion of inflammation and cancer development. Hypoxia-inducible factor-1α (HIF-1α) is involved in the hypoxia response and cancer promotion, and it accumulates in hypoxia and is degraded under normoxic conditions. Here we identi...

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Bibliographic Details
Main Authors: Jianlong Wang, Xuyi Chen, Haijuan Hu, Mengting Yao, Yanbiao Song, Aimin Yang, Xiuhua Xu, Ning Zhang, Jianzhao Gao, Bin Liu
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
breast cancer
HIF-1α
hypoxia
PCAT-1
RACK1
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312100069X

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http://www.sciencedirect.com/science/article/pii/S216225312100069X

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