A serological type II collagen neoepitope biomarker reflects cartilage breakdown in patients with osteoarthritis

A serological type II collagen neoepitope biomarker reflects cartilage breakdown in patients with osteoarthritis

Objectives: There is an unmet medical need for biomarkers in OA which can be applied in clinical drug development trials. The present study describes the development of a specific and robust assay measuring type II collagen degradation (T2CM) and discusses its potential as a noninvasive translationa...

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Bibliographic Details
Main Authors: Solveig Skovlund Groen, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Christian S. Thudium, Morten A. Karsdal, Simon Francis Thomsen, Sven Lindemann, Daniela Werkmann, Joseph Blair, Line Mærsk Staunstrup, Patrik Önnerfjord, Lars Arendt-Nielsen, Signe Holm Nielsen
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Biomarker
Extracellular matrix
Cartilage
Type II collagen
T2CM
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913121000704

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