EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production

Endoplasmic reticulum (ER) degradation-enhancing α-mannosidase-like protein 1 (EDEM1) is a quality control factor directly involved in the endoplasmic reticulum-associated degradation (ERAD) process. It recognizes terminally misfolded proteins and directs them to retrotranslocation which is followed...

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Bibliographic Details
Main Authors: Jowita Nowakowska-Gołacka, Justyna Czapiewska, Hanna Sominka, Natalia Sowa-Rogozińska, Monika Słomińska-Wojewódzka
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
endoplasmic reticulum degradation-enhancing α-mannosidase-like 1 protein (EDEM1)
amyloid-β precursor protein (APP)
endoplasmic reticulum-associated degradation (ERAD)
amyloid-β (Aβ)
endoplasmic reticulum (ER)
protein degradation
Online Access:https://www.mdpi.com/1422-0067/23/1/117

Internet

https://www.mdpi.com/1422-0067/23/1/117

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