G10 is a direct activator of human STING

G10 is a direct activator of human STING

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The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and activate the adaptor STING, leading to downstream secretion of Type I interferons and other pro-inflammatory NFκB pathway cytokines. In the m...

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Bibliographic Details
Main Authors: Monali Banerjee, Sandip Middya, Ritesh Shrivastava, Sourav Basu, Rajib Ghosh, David C. Pryde, Dharmendra B. Yadav, Arjun Surya, Michael Nevels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482845/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482845/?tool=EBI

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