G10 is a direct activator of human STING
The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and activate the adaptor STING, leading to downstream secretion of Type I interferons and other pro-inflammatory NFκB pathway cytokines. In the m...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482845/?tool=EBI |
| _version_ | 1818848693919416320 |
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| author | Monali Banerjee Sandip Middya Ritesh Shrivastava Sourav Basu Rajib Ghosh David C. Pryde Dharmendra B. Yadav Arjun Surya Michael Nevels |
| author_facet | Monali Banerjee Sandip Middya Ritesh Shrivastava Sourav Basu Rajib Ghosh David C. Pryde Dharmendra B. Yadav Arjun Surya Michael Nevels |
| author_sort | Monali Banerjee |
| collection | DOAJ |
| description | The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and activate the adaptor STING, leading to downstream secretion of Type I interferons and other pro-inflammatory NFκB pathway cytokines. In the mouse, the STING driven innate immune response is central to immune based clearance of various tumors and this has triggered a significant effort focused on the discovery of human STING agonists for the treatment of cancer. This report uses an in vitro kinase assay to show that G10, a previously identified STING pathway activator is actually a weak but direct STING agonist and identifies other more potent leads. |
| first_indexed | 2024-12-19T06:21:24Z |
| format | Article |
| id | doaj.art-dbeee285ed174e5593563086cb947d31 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T06:21:24Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dbeee285ed174e5593563086cb947d312022-12-21T20:32:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01159G10 is a direct activator of human STINGMonali BanerjeeSandip MiddyaRitesh ShrivastavaSourav BasuRajib GhoshDavid C. PrydeDharmendra B. YadavArjun SuryaMichael NevelsThe cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and activate the adaptor STING, leading to downstream secretion of Type I interferons and other pro-inflammatory NFκB pathway cytokines. In the mouse, the STING driven innate immune response is central to immune based clearance of various tumors and this has triggered a significant effort focused on the discovery of human STING agonists for the treatment of cancer. This report uses an in vitro kinase assay to show that G10, a previously identified STING pathway activator is actually a weak but direct STING agonist and identifies other more potent leads.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482845/?tool=EBI |
| spellingShingle | Monali Banerjee Sandip Middya Ritesh Shrivastava Sourav Basu Rajib Ghosh David C. Pryde Dharmendra B. Yadav Arjun Surya Michael Nevels G10 is a direct activator of human STING PLoS ONE |
| title | G10 is a direct activator of human STING |
| title_full | G10 is a direct activator of human STING |
| title_fullStr | G10 is a direct activator of human STING |
| title_full_unstemmed | G10 is a direct activator of human STING |
| title_short | G10 is a direct activator of human STING |
| title_sort | g10 is a direct activator of human sting |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482845/?tool=EBI |
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