Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2

Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2

Abstract Hydroxycarboxylic acid receptor 2 (HCAR2), a member of Class A G-protein-coupled receptor (GPCR) family, plays a pivotal role in anti-lipolytic and anti-inflammatory effects, establishing it as a significant therapeutic target for treating dyslipidemia and inflammatory diseases. However, th...

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Bibliographic Details
Main Authors: Lin Cheng, Suyue Sun, Heli Wang, Chang Zhao, Xiaowen Tian, Ying Liu, Ping Fu, Zhenhua Shao, Renjie Chai, Wei Yan
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01625-y

Internet

https://doi.org/10.1038/s41392-023-01625-y

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