Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Bispecific T-cell-engaging antibodies are a growing class of therapeutics with numerous molecules being tested in clinical trials and, currently, seven of them have received market approval. They are structurally complex and function as adaptors to redirect the cytotoxicity of T cells to kill tumor...

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Autors principals: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M. Falkowski, Thomas G. Biel, Tongzhong Ju, Wen Jin Wu
Format: Article
Idioma:English
Publicat: Frontiers Media S.A. 2024-05-01
Col·lecció:Frontiers in Immunology
Matèries:
bispecific antibody
bispecific T-cell engager
epidermal growth factor receptor (EGFR)
cluster of differentiation 3 (CD3)
dual variable domain immunoglobulins (DVD-Ig)
Accés en línia:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

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