Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Bispecific T-cell-engaging antibodies are a growing class of therapeutics with numerous molecules being tested in clinical trials and, currently, seven of them have received market approval. They are structurally complex and function as adaptors to redirect the cytotoxicity of T cells to kill tumor...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M. Falkowski, Thomas G. Biel, Tongzhong Ju, Wen Jin Wu
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2024-05-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
bispecific antibody
bispecific T-cell engager
epidermal growth factor receptor (EGFR)
cluster of differentiation 3 (CD3)
dual variable domain immunoglobulins (DVD-Ig)
Online Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

Online

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

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