Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Bispecific T-cell-engaging antibodies are a growing class of therapeutics with numerous molecules being tested in clinical trials and, currently, seven of them have received market approval. They are structurally complex and function as adaptors to redirect the cytotoxicity of T cells to kill tumor...

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Detalles Bibliográficos
Autores principales: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M. Falkowski, Thomas G. Biel, Tongzhong Ju, Wen Jin Wu
Formato: Artículo
Lenguaje:English
Publicado: Frontiers Media S.A. 2024-05-01
Colección:Frontiers in Immunology
Materias:
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full