Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Bispecific T-cell-engaging antibodies are a growing class of therapeutics with numerous molecules being tested in clinical trials and, currently, seven of them have received market approval. They are structurally complex and function as adaptors to redirect the cytotoxicity of T cells to kill tumor...

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Bibliografische gegevens
Hoofdauteurs: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M. Falkowski, Thomas G. Biel, Tongzhong Ju, Wen Jin Wu
Formaat: Artikel
Taal:English
Gepubliceerd in: Frontiers Media S.A. 2024-05-01
Reeks:Frontiers in Immunology
Onderwerpen:
bispecific antibody
bispecific T-cell engager
epidermal growth factor receptor (EGFR)
cluster of differentiation 3 (CD3)
dual variable domain immunoglobulins (DVD-Ig)
Online toegang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

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