Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Bispecific T-cell-engaging antibodies are a growing class of therapeutics with numerous molecules being tested in clinical trials and, currently, seven of them have received market approval. They are structurally complex and function as adaptors to redirect the cytotoxicity of T cells to kill tumor...

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Detalhes bibliográficos
Main Authors: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M. Falkowski, Thomas G. Biel, Tongzhong Ju, Wen Jin Wu
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2024-05-01
Colecção:Frontiers in Immunology
Assuntos:
bispecific antibody
bispecific T-cell engager
epidermal growth factor receptor (EGFR)
cluster of differentiation 3 (CD3)
dual variable domain immunoglobulins (DVD-Ig)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

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