Targeted gut microbiota manipulation attenuates seizures in a model of infantile spasms syndrome

Targeted gut microbiota manipulation attenuates seizures in a model of infantile spasms syndrome

Infantile spasms syndrome (IS) is a devastating early-onset epileptic encephalopathy associated with poor neurodevelopmental outcomes. When first-line treatment options, including adrenocorticotropic hormone and vigabatrin, are ineffective, the ketogenic diet (KD) is often employed to control seizur...

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Bibliographic Details
Main Authors: Chunlong Mu, Naghmeh Nikpoor, Thomas A. Tompkins, Anamika Choudhary, Melinda Wang, Wendie N. Marks, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-06-01
Series:JCI Insight
Subjects:
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.158521

Internet

https://doi.org/10.1172/jci.insight.158521

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