Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

Background Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological mechanisms remain unknown. Methods and Results Cardiom...

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Bibliographic Details
Main Authors: Shafiul Alam, Chowdhury S. Abdullah, Richa Aishwarya, Sumitra Miriyala, Manikandan Panchatcharam, Jonette M. Peretik, A. Wayne Orr, Jeanne James, Jeffrey Robbins, Md. Shenuarin Bhuiyan
Format: Article
Language:English
Published: Wiley 2018-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiomyopathy
desminopathy
mitochondrial fission
mitochondrial respiration
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.009289

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009289

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