Multiple Administration Routes, Including Intramuscular Injection, of Oncolytic Tanapoxvirus Variants Significantly Regress Human Melanoma Xenografts in BALB/c Nude Mice Reconstituted with Splenocytes from Normal BALB/c Donors

Multiple Administration Routes, Including Intramuscular Injection, of Oncolytic Tanapoxvirus Variants Significantly Regress Human Melanoma Xenografts in BALB/c Nude Mice Reconstituted with Splenocytes from Normal BALB/c Donors

Human melanoma is the most aggressive form of skin cancer and is responsible for the most deaths of all skin cancers. Localized tumors, and those which have limited spread, have 5-year survival rates of over 90%, with those numbers steadily rising over the past decade. However, metastatic melanomas...

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Bibliographic Details
Main Authors: Michael L. Monaco, Omer A. Idris, Grace A. Filpi, Steven L. Kohler, Scott D. Haller, Jeffery E. Burr, Robert Eversole, Karim Essani
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Genes
Subjects:
melanoma
immuno-oncolytic viruses
xenograft
adoptive transfer
immune reconstitution
tanapoxvirus
Online Access:https://www.mdpi.com/2073-4425/14/8/1533

Internet

https://www.mdpi.com/2073-4425/14/8/1533

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