Activation of Sirtuin 1 Attenuates High Glucose-Induced Neuronal Apoptosis by Deacetylating p53

Activation of Sirtuin 1 Attenuates High Glucose-Induced Neuronal Apoptosis by Deacetylating p53

Diabetes mellitus (DM) has been proven to be a key risk factor for cognitive impairment. Previous studies have implicated hippocampal neuronal apoptosis in diabetes-related cognitive impairment. However, the underlying mechanism remains unknown. Sirtuin 1 (SIRT1) is a protein deacetylase depended on...

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Bibliographic Details
Main Authors: Xiajie Shi, Linhua Pi, Shanlei Zhou, Xin Li, Fangyuan Min, Shan Wang, Zhenqi Liu, Jing Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Endocrinology
Subjects:
diabetes
cognitive impairment
sirtuin 1
neuronal apoptosis
p53
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00274/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00274/full

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