Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis

Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis

It is well known that Semaphorin 4D (Sema4D) inhibits IGF-1-mediated osteogenesis by binding with PlexinB1 expressed on osteoblasts. However, its elevated level in the gingival crevice fluid of periodontitis patients and the broader scope of its activities in the context of potential upregulation of...

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Bibliographic Details
Main Authors: Takenobu Ishii, Montserrat Ruiz-Torruella, Kenta Yamamoto, Tsuguno Yamaguchi, Alireza Heidari, Roodelyne Pierrelus, Elizabeth Leon, Satoru Shindo, Mohamad Rawas-Qalaji, Maria Rita Pastore, Atsushi Ikeda, Shin Nakamura, Hani Mawardi, Umadevi Kandalam, Patrick Hardigan, Lukasz Witek, Paulo G. Coelho, Toshihisa Kawai
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
periodontitis
Semaphorin 4D
bone regeneration
osteoblasts
osteoclasts
Online Access:https://www.mdpi.com/1422-0067/23/10/5630

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https://www.mdpi.com/1422-0067/23/10/5630

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