Overcoming MDR by Associating Doxorubicin and pH-Sensitive PLGA Nanoparticles Containing a Novel Organoselenium Compound—An In Vitro Study

Overcoming MDR by Associating Doxorubicin and pH-Sensitive PLGA Nanoparticles Containing a Novel Organoselenium Compound—An In Vitro Study

In this study, we developed PLGA nanoparticles (NPs) as an effective carrier for 5′-Se-(phenyl)-3-(amino)-thymidine (ACAT-Se), an organoselenium compound, nucleoside analogue that showed promising antitumor activity in vitro. The PLGA NPs were prepared by the nanoprecipitation method and modified wi...

Full description

Bibliographic Details
Main Authors: Letícia Bueno Macedo, Daniele Rubert Nogueira-Librelotto, Daniela Mathes, Josiele Melo de Vargas, Raquel Mello da Rosa, Oscar Endrigo Dorneles Rodrigues, Maria Pilar Vinardell, Montserrat Mitjans, Clarice Madalena Bueno Rolim
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
selenium compounds
pH-responsive nanoparticles
combination therapy
tumor cell lines
multidrug resistance (MDR)
Online Access:https://www.mdpi.com/1999-4923/14/1/80

Internet

https://www.mdpi.com/1999-4923/14/1/80

Similar Items