Chromosomal aberrations after induced pluripotent stem cells reprogramming

Chromosomal aberrations after induced pluripotent stem cells reprogramming

Abstract Induced pluripotent stem cells (iPSCs) are generated from adult cells that have been reprogrammed to pluripotency. However, in vitro cultivation and genetic reprogramming increase genetic instability, which could result in chromosomal abnormalities. Maintenance of genetic stability after re...

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Bibliographic Details
Main Authors: Isadora May Vaz, Tamara Borgonovo, Tais Hanae Kasai-Brunswick, Danúbia Silva dos Santos, Fernanda Cristina Paccola Mesquita, Juliana Ferreira Vasques, Fernanda Gubert, Carmen Lúcia Kuniyoshi Rebelatto, Alexandra Cristina Senegaglia, Paulo Roberto Slud Brofman
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2021-09-01
Series:Genetics and Molecular Biology
Subjects:
Genetic instability
cytogenetics
iPSC
chromosomal aberration
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000400103&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000400103&tlng=en

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