High Cell Density Cultivation Process for the Expression of Botulinum Neurotoxin a Receptor Binding Domain

High Cell Density Cultivation Process for the Expression of Botulinum Neurotoxin a Receptor Binding Domain

The receptor-binding domain of botulinum neurotoxin (H<sub>C</sub> fragment), is a promising botulism vaccine candidate. In the current study, fermentation strategies were evaluated to upscale H<sub>C</sub> fragment expression. A simple translation of the growth conditions fr...

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Bibliographic Details
Main Authors: Alon Ben David, Yoel Papir, Ophir Hazan, Moses Redelman, Eran Diamant, Ada Barnea, Amram Torgeman, Ran Zichel
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Toxins
Subjects:
<i>Clostridium botulinum</i>
subunit vaccine
recombinant protein expression
fermentation
high cell density cultivation
Online Access:https://www.mdpi.com/2072-6651/14/4/281

Internet

https://www.mdpi.com/2072-6651/14/4/281

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