MHC class I bound to an immunodominant Theileria parva epitope demonstrates unconventional presentation to T cell receptors.

MHC class I bound to an immunodominant Theileria parva epitope demonstrates unconventional presentation to T cell receptors.

T cell receptor (TCR) recognition of peptide-MHC class I (pMHC) complexes is a crucial event in the adaptive immune response to pathogens. Peptide epitopes often display a strong dominance hierarchy, resulting in focusing of the response on a limited number of the most dominant epitopes. Such T cell...

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Bibliographic Details
Main Authors: Isabel K Macdonald, Maria Harkiolaki, Lawrence Hunt, Timothy Connelley, A Victoria Carroll, Niall D MacHugh, Simon P Graham, E Yvonne Jones, W Ivan Morrison, Darren R Flower, Shirley A Ellis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20976198/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20976198/?tool=EBI

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