Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.

Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.

The human immunity-related GTPase M (IRGM) has been shown to be critically involved in regulating autophagy as a means of disposing cytosolic cellular structures and of reducing the growth of intracellular pathogens in vitro. This includes Mycobacterium tuberculosis, which is in agreement with findi...

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Bibliographic Details
Main Authors: Christopher D Intemann, Thorsten Thye, Stefan Niemann, Edmund N L Browne, Margaret Amanua Chinbuah, Anthony Enimil, John Gyapong, Ivy Osei, Ellis Owusu-Dabo, Susanne Helm, Sabine Rüsch-Gerdes, Rolf D Horstmann, Christian G Meyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19750224/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19750224/pdf/?tool=EBI

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