The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import

The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import

Nipah and Hendra viruses are highly pathogenic, zoonotic henipaviruses that encode proteins that inhibit the host’s innate immune response. The W protein is one of four products encoded from the P gene and binds a number of host proteins to regulate signalling pathways. The W protein is intrinsicall...

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Bibliographic Details
Main Authors: Sofiya Tsimbalyuk, Emily M. Cross, Mikayla Hoad, Camilla M. Donnelly, Justin A. Roby, Jade K. Forwood
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
intrinsically disordered
W protein
henipaviruses
STAT
IRF-3
Online Access:https://www.mdpi.com/2073-4409/9/8/1913

Internet

https://www.mdpi.com/2073-4409/9/8/1913

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