17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Abstract Background Parkinson’s disease (PD) is genetically associated with the H1 haplotype of the MAPT 17q.21.31 locus, although the causal gene and variants underlying this association have not been identified. Methods To better understand the genetic contribution of this region to PD and to iden...

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Bibliographic Details
Main Authors: Kathryn R. Bowles, Derian A. Pugh, Yiyuan Liu, Tulsi Patel, Alan E. Renton, Sara Bandres-Ciga, Ziv Gan-Or, Peter Heutink, Ari Siitonen, Sarah Bertelsen, Jonathan D. Cherry, Celeste M. Karch, Steven J. Frucht, Brian H. Kopell, Inga Peter, Y. J. Park, International Parkinson’s Disease Genomics Consortium (IPDGC), Alexander Charney, Towfique Raj, John F. Crary, A. M. Goate
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Molecular Neurodegeneration
Subjects:
17q21.31
Parkinson’s disease
LRRC37A
Copy number variation
Astrocytes
Online Access:https://doi.org/10.1186/s13024-022-00551-x

Internet

https://doi.org/10.1186/s13024-022-00551-x

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