Estimating microhaplotype allele frequencies from low-coverage or pooled sequencing data

Estimating microhaplotype allele frequencies from low-coverage or pooled sequencing data

Abstract Background Microhaplotypes have the potential to be more cost-effective than SNPs for applications that require genetic panels of highly variable loci. However, development of microhaplotype panels is hindered by a lack of methods for estimating microhaplotype allele frequency from low-cove...

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Bibliographic Details
Main Authors: Thomas A. Delomas, Stuart C. Willis
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Bioinformatics
Subjects:
Low-depth whole genome sequencing
Skim-seq
Pool-seq
Microhaplotype
Genotype panel design
Online Access:https://doi.org/10.1186/s12859-023-05554-z

Internet

https://doi.org/10.1186/s12859-023-05554-z

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