Lorcaserin Alters Serotonin and Noradrenaline Tissue Content and Their Interaction With Dopamine in the Rat Brain

Lorcaserin Alters Serotonin and Noradrenaline Tissue Content and Their Interaction With Dopamine in the Rat Brain

Lorcaserin is a preferential serotonin2C receptor (5-HT2CR) agonist effective to treat obesity that has also recently been proposed to treat addiction and epilepsy. Central dopamine (DA) mechanisms are likely involved in the lorcaserin mechanism of action, but other monoamines 5-HT and noradrenaline...

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Bibliographic Details
Main Authors: Giuseppe Di Giovanni, Rahul Bharatiya, Emilie Puginier, Marta Ramos, Salomé De Deurwaerdère, Abdeslam Chagraoui, Philippe De Deurwaerdère
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
monoamines
correlation
brain
high-pressure liquid chromatography
electrochemical detection
cortex
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00962/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00962/full

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